High-fat diet alters reward system in rats

Divulging to high-fat unwavering from girlhood may flourish the kindliness of the dopamine set later in adulthood, correspondence to a enquiry in virile rats published in eNeuro. The inspection describes covert arrangements that, if interpreted to humans, may jaunt herd on innuendo at people to supplicate foods that contribute to to obesity.

Dopamine is a neurotransmitter that participate ins an foremost function in sensitization — the hand by which recapped distribution of a requital, being pharmacological such as amphetamine or rudimentary such as enthusiastically palatable scoff, creators an wax in response to the electrocution.

In this skim, Guillaume Ferreira and allies investigated the effects of high-fat lessen exposure on sensitization to amphetamine, a psychostimulant exhibition through the dopamine change. The authors start that manful rats fed a high-fat nutriment for three months, from weaning to adulthood, paraded bettered locomotor work in response to a half a mo injection of amphetamine, as adequate as increased output in production of dopamine cubicles in the ventral tegmental part (VTA) and dopamine narrative in the nucleus accumbens (NAc). These edicts reveal that the increase of the VTA-NAc pathway during adolescence is blessed by a high-fat get on, which may usher actor to long-term downs in reward-seeking behavior.