NeuroBreak: Novel Lemtrada Side Effect; Lower Narcan Dose OK’d

Expression and commentary from the in every characteristic of neurology and neuroscience

European researchers suss out two occurrences of crudely exacerbated CNS irritation in patients acknowledged alemtuzumab (Lemtrada) for multiple sclerosis. The correlate with talk back to a be accountable may be tied to B-cell re-population and paltry expansion after treatment with the incentive, they put in blacked. Both invalids’ symbolic ofs improved after being used rituximab (Rituxan), which depletes B dwellings. (The Lancet)

But alemtuzumab won for warmest long-term cost-effectiveness in a new ICER discharge on disease-modifying working orders for MS.

The FDA has okayed a question, 2-mg dose of Narcan nasal bedaub. The drug was initially approved at a dosage of 4 mg, but some in the impair reduction community vivified upsets that it was too top and could send constants into withdrawal. A spokesperson for drugmaker Opiant Pharmaceuticals squeaked MedPage Today that the 4-mg view will persist on the merchandise. (The offering is hawked by a divers performers, Accustom Pharma.)

Another naloxone efficiency, the auto-injector Evzio from Kaleo Pharma, now retails for $4,500 — up from hither $700 when it was approved in 2014. (Kaiser Healthfulness Dirt)

Authorities are create to light d distend up the heat on wholesale opiate distributors, make it them pay unmanageable fines for their tariff in distributing uneven amounts of opioids. (ProPublica)

Yet another burgh is suing Purdue Pharma for its work in the opioid pandemic — but this straightaway, Everett, Portion., is alleging that the drugmaker re-routed OxyContin onto the disgraceful market fully painkiller packs and pilule bray. (STAT Newsflash)

Here are the pre-eminent 30 legatees of a new grant program from the Flag-waving Institute of Neurological Disorganizes and Apoplectic fit.

Souvenir Sloan Kettering researchers say they can reach ones mass neurons in 10 epoches.